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By A. Andreatti, W. Stoll

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The ENCODE Project Consortium. Nature 2012, 489, 57–74. 71. ; Royce, T. ; Rozowsky, J. ; Urban, A. ; Rinn, J. ; Snyder, M. Science 2004, 306, 2242–2246. 72. Johnson, J. ; Loerch, P. ; Armour, C. ; Schadt, E. ; Shoemaker, D. D. Science 2003, 302, 2141–2144. 73. Stoeckert, C. ; Causton, H. ; Ball, C. A. Nat. Genet. 2002, 32S, 469–473. 74. ; Ball, C. ; Causton, H. ; Holstege, F. ; Kim, I. ; Matese, J. ; Vingron, M. Nat. Genet. 2001, 29, 365–371. 75. ; Lash, A. E. Nucleic Acids Res. 2002, 30, 207–210.

Genotyping arrays, on the other hand, have fewer obstacles to overcome in gaining regulatory approval as well as clinical acceptance. Because they are usually aiming to characterize well-known and previously established sequence variation among the genome, it does not have to prove clinical correlation and utility. Nevertheless, these arrays are still required to be technically reliable and competitive in price. Low-throughput genotyping arrays use a fairly small number of features (up to a few hundred on a chip) for characterization of a pathogen or investigation of several SNP sites in a particular gene at a relatively inexpensive price.

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Analytic and Algebraic Dependence of Meromorphic Fns by A. Andreatti, W. Stoll


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